Hairy cell leukaemia: a heterogeneous disease?
نویسندگان
چکیده
منابع مشابه
Hairy cell leukaemia.
Hairy cell leukaemia is a rare form of lymphoproliferative disease that affects 2% of leukaemia patients and was first described in 1958 as leukaemic reticuloendotheliosis. The typical presentation is pancytopenia, splenomegaly and abnormal lymphoid cells in blood with hairy cytoplasmic projections. The pathological hairy cell resembles in many ways B-lymphocyte as in chronic lymphocytic leukae...
متن کاملHairy cell leukaemia with T cell features.
A case of clinically and hematologically typical hairy-cell leukemia has been presented in which, at the various times of testing, 52%-95% of peripheral blood and 73% of splenic mononuclear cells formed spontaneous sheep erythrocyte (E) rosettes. Many of the rosetting cells were shown to be typical morphologic hairy cells by light and electron microscopy. It was found that 70%-75% of peripheral...
متن کاملRevised guidelines for the diagnosis and management of hairy cell leukaemia and hairy cell leukaemia variant*.
The British Committee for Standards in Haematology first produced guidelines for the diagnosis and management of hairy cell leukaemia and hairy cell leukaemia variant in 2000. This revision updates those guidelines and covers the areas of diagnosis, treatment and assessment of response to therapy.
متن کاملKaposi's sarcoma associated with hairy cell leukaemia.
Hairy cell leukaemia is a rare condition and the patient reported here is only the third such case out of 527 patients with all types of leukaemia seen at our hospital over the last 4 years. A second malignancy in a patient with hairy cell leukaemia has been documented in detail only once before (Adler, Shetty and Golomb, 1979). The association of Kaposi's sarcoma, a common tumour in parts of s...
متن کاملHairy cell leukaemia--diagnosis and current treatment.
Hairy cell leukaemia is a chronic B cell disorder which runs an an indolent but progressive course characterized by cytopenia, recurrent infections and splenomegaly. The hallmark of this disease is the presence of cells with filiform cytoplasmic surface projections in peripheral blood and/or bone marrow. In recent years the introduction of new chemotherapeutic agents has revolutionized the trea...
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ژورنال
عنوان ژورنال: British Journal of Haematology
سال: 2008
ISSN: 0007-1048,1365-2141
DOI: 10.1111/j.1365-2141.2008.07156.x